Loading Hyaluronic acid- Functionalized Zinc Ferrite Nanoparticles with the Drug Doxorubicin

Abstract

Cancer is considered one of the most prevalent diseases worldwide and is one of the leading causes of death today. There are several methods for treating cancer, the most prominent of which is chemotherapy, which uses Doxorubicin as one of the cancer treatment drugs. However, due to the many severe side effects of Doxorubicin, the current research is focusing on developing Targeted Drug Delivery Systems to direct this medicine more effectively. This system may consist of a nanocarrier, targeting molecules, and Doxorubicin.

In this study, Doxorubicin was loaded onto hyaluronic acid – functionalized zinc ferrite nanoparticles (ZF@HA), resulting in ZF@HA@Dox nanoparticles with a loading rate of 8.95% and a loading efficiency of 41.31%. The study also demonstrated that 90% of the loaded Doxorubicin was released in cancer cell medium within the first 24 hours.